Ever since the dawn of civilization we have been driven by a desire to know--to understand the physical world and the laws of nature. But are there limits to human knowledge? Are some things beyond the predictive powers of science, or are those challenges simply the next big discovery waiting to happen?Marcus du Sautoy takes us into the minds of science's greatest innovators and reminds us that major breakthroughs were often ridiculed at the time of their discovery. Then he carries us on a whirlwind tour of seven "Edges" of knowledge - inviting us to consider the problems in quantum physics, cosmology, probability and neuroscience that continue to bedevil scientists who are at the front of their fields. He grounds his personal exploration of some of science's thorniest questions in simple concepts like the roll of dice, the notes of a cello, or how a clock measures time.